Potential Drug Interactions

Potential Drug Interactions: What you need to know

  • Plavix and Proton Pump Inhibitors: Losec, omeprazole, Prevacid, lansoprazole, Pariet, rabeprazole, Nexium, and esomeprazole
  • ACE-Inhibitors and ARBs: It is safe to take both?

Plavix and Proton Pump Inhibitors: Losec, omeprazole, Prevacid, lansoprazole, Pariet, rabeprazole, Nexium, and esomeprazole

You may have seen a story aired on CTV in late January 2009 warning about the risk of taking Plavix in conjunction with medication used for acid control. This information is based on a recent study published in the Canadian Medical Journal. The study concluded that patients who took Plavix and one of the above proton pump inhibitors were at risk of experiencing a second heart attack. The study also found that the proton pump inhibitor pantoprazole did not interact with Plavix.

If you are taking one of the proton pump inhibitors mentioned above, we recommend contacting your doctor or pharmacist in order to discontinue this medication. It is important that you continue to take your Plavix as directed. If you are taking pantoprazole we recommend continuing your current medication regimen.

For more information or if you have any questions please contact a Stueck Pharmacy pharmacist at 628-3744

ACE-Inhibitors and ARBs: It is safe to take both?

The Heart and Stroke Foundation of Canada released recent guidelines on the use of ACE Inhibitors and ARBs in combination. ACE-Inhibitors include ramipril, enalapril, captoril, lisinopril, perindopril, and quinapril. ARBs include irbesartan, losartan, valsartan, and telmisartan.

The information is based on hypertension guidelines from a recent trial. Both medications act through a similar mechanism and taking both in combination may cause an increase in the amount or severity of side effects experienced, with a minimal blood pressure benefit. There have been other studies testing the benefit and risk of combination therapy. The decision to use one or both is often not easily made and depends on many factors. An ACE-Inhibitor/ARB combination is generally not recommended if you:

  • Have high blood pressure alone without other conditions
  • Have diabetes without kidney damage
  • Have angina alone
  • Have recently had a heart attack
  • Have experienced a stroke or mini-stroke
  • Uncomplicated chronic kidney disease

However, it is important that you do not stop your medication without consulting a health care professional. Each person is unique and an ACE-Ihibitor/ARB combination may be appropriate in your situation. We recommend speaking to your doctor or pharmacist if you would like to discuss your options or if you have any concerns.

For more information or if you have any questions please contact a Stueck Pharmacy pharmacist at 628-3744